Full Name: Botulinum neurotoxin type A light chain
Synonyms: BoNT/A LC
Botulinum neurotoxin A light chain is a zinc-dependent endopeptidase catalytic domain produced by Clostridium botulinum. Once translocated into the neuronal cytosol, it selectively cleaves SNAP-25, blocking acetylcholine release at neuromuscular junctions and causing flaccid paralysis. Its structure contains a catalytic zinc-binding motif (HEXXH).