Design and Synthesis of Haptens for Salinomycin

As an expert in the field of small-molecule antibody discovery, Creative Biolabs is helping our customers with various hapten design and synthesis services targeting salinomycin. Based on our deep analytical capabilities and vast experience in hapten studies, our client-focused, integrated team will anticipate challenges, overcome difficulties and provide custom small-molecule hapten studies with numerous assays. We guarantee the finest results for our customers all over the world.

Introduction to Salinomycin

Salinomycin is a type of anti-bacterial antibiotic that has been widely used for treating infectious diseases in mammals. In general, salinomycin is a monocarboxylic polyether antimicrobial drug with a size of 750 Da and is usually composed of a tricyclic spiroketal ring and a special six-membered ring. Moreover, previous studies have demonstrated that salinomycin plays an important role in mediating the transport of cations, including K⁺ and Ca²⁺, through cell membranes of specific bacteria. In addition, pilot studies have suggested that salinomycin has an anti-tumor activity that can overcome the drug resistance or chemoresistance in a number of human cancer cell types, such as breast cancer cells. As a result, it has been considered as a potential anti-cancer agent for the treatment of various cancers both in preclinical trials and clinical trials. meanwhile, the haptens for salinomycin have been designed to provide a long-term anti-tumor immune response for cancer therapy.

Fig.1 Structure of salinomycin. (Zhou, 2013)

Our Platform for Design and Synthesis of Salinomycin Haptens

The drug-like hapten design is a key part of generating different kinds of antibodies against small molecules. The specific chemical composition and target molecular properties of new haptens are capable of improving the efficacy of these antibodies in treating various medical problems. Many reports have shown that the design and synthesis of novel haptens have been used to develop novel monoclonal antibodies (mAb) targeting a variety of polyethers antibiotics, especially for salinomycin. The results have indicated that the mAbs generated from immunization with different salinomycin haptens have a higher affinity and specificity for preventing infections and treating human cancers.

Therefore, Creative Biolabs has generated a novel platform to design, synthesize, evaluate and modify potential haptens for salinomycin. In a recent study, several haptens for salinomycin have been designed and synthesized by our labs to generate mAb. Meanwhile, these haptens can be conjugated to different carrier proteins, such as bovine serum albumin (BSA) and ovalbumin (OVA), to obtain the most effective hapten antigens. Furthermore, we also offer a series of assays to analyze the relationship between hapten length, affinity, and specificity.

Creative Biolabs is dedicated to expanding cutting edge antibody research across a range of applications. With our proven competencies and regulatory expertise, we are therefore confident in offering the best services targeting salinomycin haptens. We can provide many flexible options, from which you can always find a better match for your particular project. If you are interested in our services, please contact us for more details.

Reference

1. Zhou, S.; et al. Salinomycin: a novel anti-cancer agent with known anti-coccidial activities. Current medicinal chemistry. 2013, 20(33): 4095-4101.